Manufacturing
Kovaltry has been produced with Bayer’s recombinant FVIII
manufacturing technology1*
Full-length recombinant FVIII molecule
Full-length recombinant FVIII molecule
- Identical FVIII amino acid sequence as Kogenate® FS†
Uses a gene that encodes HSP70 into the BHK cell line‡
Uses a gene that encodes HSP70 into the BHK cell line‡
- Addition of the HSP70 chaperone protein to enhance proper FVIII folding and resistance to apoptosis
- Oligosaccharide characterization has shown superior glycosylation, better branching and sialylation capping of terminal galactose residues compared to Kogenate® FS†
HSP70=human heat shock protein 70; BHK=baby hamster kidney.
* Clinical significance has not been established.
† Comparative clinical significance has not been established.
‡ HSP70 acts as a chaperone to enhance proper protein folding as it is being assembled.
