Jivi® Dosing

Jivi dosing

Jivi offers prophylaxis dosing for adults and adolescents^1*

Dosage of Jivi should be individualized based on patient characteristics and treatment response

Adapted from Jivi Product Monograph.

Variables to consider when individualizing the dose and duration of Jivi¹

Weight
Severity of the hemostatic function disorder

Site and extent/severity of the bleeding
Desired Factor VIII (FVIII) level

Pharmacokinetic and clinical response

On-demand treatment with Jivi^1*

Dosage necessary to achieve hemostasis depends on the type and severity of the bleeding episode¹

FVIII activity should not fall below the given plasma activity level (in % of normal or IU/dL) in the corresponding period for the following hemorrhagic events:¹

	FVIII level required	Recommended dose	Frequency of doses and duration of therapy
Minor hemorrhage^†	20–40^% or IU/dL	10–20 IU/kg	Repeat every 24–48 hours until bleeding resolved
Moderate hemorrhage^‡	30–60^% or IU/dL	15–30 IU/kg	Repeat every 24–48 hours until bleeding resolved
Major hemorrhage^§	60–100^% or IU/dL	30–50 IU/kg	Repeat every 8–24 hours until bleeding resolved

Adapted from Jivi Product Monograph.

Minor hemorrhage^†

Moderate hemorrhage^‡

Major hemorrhage^§

Adapted from Jivi Product Monograph.

Perioperative management with Jivi^1*

Consider maintaining a FVIII activity at or above the target range¹

	FVIII level required	Recommended dose	Frequency of doses and duration of therapy
Minor surgery^¶	30–60% or IU/dL (pre- and post-operative)	15–30 IU/kg	Repeat every 24 hours for ≥1 day until healing achieved
Major surgery^\|\|	80–100% or IU/dL (pre- and post-operative)	40–50 IU/kg	Repeat every 12–24 hours until adequate wound healing, then continue therapy for ≥7 days to maintain FVIII activity of 30–60% (IU/dL)

Adapted from Jivi Product Monograph.

Minor surgery^¶

Major surgery^||

Adapted from Jivi Product Monograph.

*Please consult the Product Monograph for full dosing and administration information.

† Minor hemorrhage includes early hemarthrosis, minor muscle or oral bleeds.

‡ Moderate hemorrhage includes more extensive hemarthrosis, muscle bleeding or hematoma.

§ Major hemorrhage includes intracranial, intra-abdominal or intrathoracic hemorrhage; gastrointestinal bleeding; central nervous system bleeding; bleeding in the retropharyngeal or retroperitoneal spaces; or iliopsoas sheath, life or limb threatening hemorrhage.

¶ Minor surgery includes tooth extraction.

|| Major surgery includes intracranial, intra-abdominal, intrathoracic or joint replacement surgery.