Jivi dosing
Prevention of bleeding (prophylaxis)
The recommended initial dose for Jivi is:
Based on bleeding episodes, the dose can be adjusted to 45–60 IU/kg every 5 days. A regimen may be further individually adjusted to more or less frequent dosing.
Jivi is given by injection into the bloodstream (intravenously).
Be sure to administer Jivi at the dose and frequency prescribed by your doctor.
Treatment of bleeding
Your doctor will calculate how much Jivi to use and how frequently you should use it to get the necessary level of Factor VIII activity in your blood.
Many factors affect your dose of Jivi and how often you should use it. These include:
- Your weight
- The severity of your hemophilia
- Where the bleed is and how serious it is
- Whether you have inhibitors and the level of inhibitors in your blood
- The level of Factor VIII that is needed
Your doctor should always adjust your dose and how often you use Jivi based on your individual needs.
Under certain circumstances, larger amounts than those calculated may be required, especially for the initial dose.
Jivi is given by injection into the bloodstream (intravenously).
Laboratory test
After treatment, it is strongly recommended that appropriate laboratory tests be performed on your plasma at suitable intervals to ensure that adequate Factor VIII levels have been reached and are maintained. For major surgery in particular, close monitoring of the treatment by means of coagulation analysis must be carried out.
If bleeding is not controlled
If the Factor VIII level in your plasma fails to reach expected levels, or if bleeding is not controlled after an adequate dose, you may have developed Factor VIII inhibitors. This must be checked by an experienced doctor. If you feel the effect of Jivi is too strong or too weak, talk to your doctor.
Patients with inhibitors
If you have been told by your doctor that you have developed Factor VIII inhibitors, you may need to use a larger amount of Jivi to control bleeding.
Do not increase your dose of Jivi you use to control your bleeding without consulting your doctor.
Duration of treatment
Your doctor will tell you how often and at what intervals Jivi is to be administered.
Usually, replacement therapy with Jivi is a lifelong treatment.
Overdose:
No symptoms of overdose with recombinant human coagulation Factor VIII have been reported.
If you think you have taken too much Jivi, contact your healthcare professional, hospital emergency department or regional poison control centre immediately, even if there are no symptoms
Missed dose
- Proceed with your next dose immediately and continue at regular intervals as advised by your doctor
- Do not take a double dose to make up for a forgotten dose
